Monday, 24 July 2017

Algorithm That Diagnoses Heart Arrhythmias

Cardiac arrhythmia is in most cases harmless extras without the disease. Both a slowing of the heart rate (bradycardia) and a speeding up of the heart rate (tachycardia) can also become life threatening. Nearly every person is affected by cardiac arrhythmia during his life.


These can be harmless or dangerous. Often they are only subjectively unpleasant ("stumbling-heart") and do not need treatment. However, untreated pre-fibrillation is accompanied by a marked increase in stroke risk. This makes it all the more important to have an early and reliable algorithm diagnosis. However, they can also lead to dangerous incidents and subsequent episodes.

But how can pre-fibrillation be detected when it occurs irregularly and the patient himself often does not notice it? An ECG - that is, the measurement of cardiac currents - is the gold standard in the algorithm diagnosis of atrial fibrillation. In that case, it can help measure cardiac currents over a longer period of time and keep the heart in view all the time. It is important that even small signals and short episodes can be perceived.

Definition and types of cardiac arrhythmia

The normal heart rate is 50 to 100 beats per minute. The heart rate is generally higher in young women than in men, presumably because in men the rest frequency decreases by frequent sports. A heart rate <50 a="" bradycardia="" called="" frequency="" is="" min="" slowed=""> 100 / min at rest is too fast (tachycardia). Both manifestations of cardiac arrhythmia can be life-threatening. They then usually occur as a result of severe structural heart disease, e.g. Heart attack, cardiac insufficiency, or heart valve defect, or in the case of congenital or severe hypertension caused by hypertension.

Cardiac arrhythmia can be divided into disturbances of stimulation and disorders of the excitatory conduction. Causes of ectopic stimulus formation can be increased automatization, abnormal automatism, and triggered activity. Excitation line disturbances can lead to arrhythmias in linear closed conduction pathways or also in the spatial whole cellular network.

Thanks to the computer scientists at Stanford, who developed an algorithm that diagnoses 14 types of Heart defects. These group of Stanford scientists led by Andrew Ng has developed this deep learning algorithm. With the collaboration with the iRhythm – the heartbeat monitoring company, roll up a solid data set that they used to teach a profound neural network model.

The new heart monitor has now been developed for this purpose. The special feature of this heart monitor, which can also be used on an outpatient basis, is its intelligent design. Its not only records the ECG, it also analyzes it and sends the most important episodes on the so-called home monitoring - a technology built into the implant - to the treating physician every day.

Thanks to this close-meshed observation of the cardiac rhythm, can be detected reliably. This is not only crucial for a safe diagnosis at the beginning of the therapy for cardiac arrhythmia- it may also be necessary to keep a close eye on the heart during treatment.

For example an ablation, that is, an intervention for the obliteration of the diseased cardiac muscle tissue, the doctor sees thanks to home monitoring, whether the procedure was successful or if again atrial fibrillation occurs. The physician can control the therapy better, and the patient gains safety.

Wednesday, 19 July 2017

Scientists Have Inserted a Gif of a Horse into Living Bacteria

Mind boggling DNA wonders!


As we know, basic Biology lessons in school and further, for people who have studied in the future, DNA has a wide spectrum usage in genomic studies as well as genetic dispositions in our entire human race. This technology news now run through our news feed every morning. Genes are what differentiates a human being from the rest of the crowd, genes are what we carry from our parents to future generations, and these molecular level proteins ultimately runs the living race in the world. From bacteria, to viruses and human beings- everything is governed by genes.

With inventions running in every genetic lab in the world, current genetic engineers and researches have managed to insert a GIF of a horse into live bacteria. Yes, shocking indeed.

Astonishing inventions!

A GIF of a moving horse has now been successfully incorporated into a bacterium, that too a live one! The genetic tool called CRISPR is often used in the genetic world for data storage purposes. It is a mind boggling wonder tool in the genetic tool which allows genetic professionals to explore the wide spectrum and possibilities of DNA and its uses in the near future. Medicine holds a lot of scope, thanks to this technology.
The technological news says that scientists in Harvard University have managed to incorporate CRISPR associated proteins called Cas1 and Cas2 as primers which will be programmed to work as a computer’s Ctrl-X tool. This enables scientists to manipulate with the DNA segments, interchange them and club them if needed.

Using the Cas1 and 2 sequences, the iconic horse GIF has been encoded and put together with high accuracy. What the CRISPR technology does is, it codes the pixel values of black and white horses and incorporates it into the genomic sequence of a live bacteria! Astonishing indeed!

The results showed spectacular multiplication of the bacteria and also hereditary patterns in the following generations.

The point of this invention is the purpose of data storage. DNA is a great device of data storage, and using this technology as per the technology news, we can access vital information about genomic studies with ease. The amount of data that a single gram of DNA can hold could possibly be information of the entire human race, all crammed into one room, which is truly insane.

DNA technologies have progressed highly over the years and will continue to do so. But with this GIF incorporation, a news meaning and growth of genomic studies and researches have been established. The wide spectrum and diversity of this technology will be a boon to the medicinal world and curing of lethal genetic diseases. Various novel syndromes and anomalies can be detected at such early stages, which would previously be unimaginable. With the hope of further growth of the technological wonders of DNA this new invention is cherished and will possibly change the way medicine is perceived.

Saturday, 1 July 2017

Grape-Based Compounds Kill Colon Cancer Stem Cells in Mice


Resveratrol – Grape Seed Extract – Treatment of Colon Cancer


As per a team of researchers, compounds from grapes could destroy Colon Cancer stem cells in a petri dish as well as in mice. Resveratrol, the compound that is found in grape skins as well as seed could ultimately also lead to treatments of supporting in the prevention of colon cancer according to Jairam K.P. Vanamala, associate professor of food sciences, Pen State.

The second leading cause of cancer-related deaths in the U.S. is colorectal cancer as per The American Cancer Society. Vanamala, who is a faculty member at the Penn State Hershey Cancer Institute, had commented that the combination of resveratrol together with grape seed extract is said to be very effective in destroying colon cancer cells and what is learnt is that the combination of these compounds is not toxic to healthy cells.

The researchers reporting their discoveries in a recent issue of BMC Complementary and Alternative Medicine recommended that the discoveries tend to make way for clinical testing of compounds on the colon cancer of human. This is said to be the second most common cancer among women and the third in men. If it tends to be successful, the compounds could be utilised in a pill in assisting in the prevention of colon cancer as well as reduce the relapse of the ailment in colon cancer survivors.

Shotgun Approach to Cancer Prevention


Vanamala had commented that they are mainlyconcerned in aiming stem cell since as per cancer stem-cell theory, cancerous tumours are driven by cancer stem cells which are capable of self-renewal, cellular differentiation and also maintain their stem cell-like appearances even after invasion and metastasis.

According to researchers, if taken in low doses, separately, resveratrol together with grape seed extract does not seem to be as effective against cancer stem-cell suppression when they are combined together.According to Vanamala, the combined effect of grape seed extract together with resveratrol could provide clues to the reasoning of why cultures with plant-based diet seems to have lower colon cancer rates.
These diets may naturally be offering a shotgun approach to cancer prevention on utilising an extensive variety of valuable compounds to aim on numerous pathways which cancer stem cells utilise to live.

Advantageous in Promoting Bacterial Diversity


Vanamala further added that this also links well with a plant-based diet which is structured in order that the person gets a bit of diverse categories of plants, of various parts of the plant with different colours of the plant.

 According to Vanamal this could be advantageous not only in promoting bacterial diversity but also in averting chronic diseases together with eradicating the colon cancer stem cells. If the human trials tend to be successful, the compound can be taken in low doses with the prevailing available supplements for grape seed extract as well as resveratrol that are also found in wine.

But he added that there seems to be some more work to be done in order to comprehend the mechanism behind the anti-cancer properties of the grape extract together with the other colourful fruits and vegetables. More study would be focused in discovering the precise anti-cancer compounds as well as enhanced understanding on how those compounds seem to work synergistically in creating much more effective colon-cancer prevention and treatment approaches.