Showing posts with label Stem Cells. Show all posts
Showing posts with label Stem Cells. Show all posts

Monday, 19 June 2017

Human Stem Cells Model the Kidney Filtration Barrier

Glomerular filtration chip devised by the human stem cells differentiation

Well, it is a relief for the ailing ones especially the kidney patients. The glomerular filtration is the new addition in terms of the kidney related diseases. The best part is that a new chip has been designed which consists of the glomerulus itself and it could bring a smile for the kidney affected persons. The therapeutic therapy has been given a new dimension post this chip manufacturing.

The kidney is one of the most important organ in our body. It is quite essential and performs a lot of functions for our body. The filtering of blood is the most important one and also helps in removing waste elements via urine. It retains the elements in the form of proteins in our body which is beneficial for the circulation of blood and proper metabolism of the body.


The main thing that helps in achieving all the above mentioned activities is none other than the glomerulus itself. There is a membrane which is thin and separates the matrix. It filters the material. The researches go on in every field. The medical field is no exception. We had recently some of the greatest discoveries in the medical arena. It has really got advanced and helped to cut down the mortality rate by a huge margin by inventing new drugs or machines.

This has been possible with the combination of science and technology which has revolutionised the world. The stem cells were under the microscope for a long time which can convert to podocytes. These can be really very helpful for the medical field. Well, the glomerular filtration was not successful when podocytes were taken into consideration in order to culture cells.


Where there is a way, there is a will. Well, certainly there is and nothing is impossible in this digital world. The solution was figured out by the scientists and developers for the glomerular filtration. The new process is something different where the podocytes which are considered to be mature are formed by separating the stem cells of human which have been induced by pluripotent.


And it works as a wonder as the success rate is close to 90 percent. Now these were embedded on a chip and a model of the glomerulus of the human as created. In this fashion, the filtration process reached a new height and all the proteins and toxic elements could be differentiated. This chip which has been developed by the researchers will play a promising role in the near future.

This will also play a key role for more research in terms of experiments and other tests. The aspect of biology will get broader and widened now a bit with the development of the glomerular filtration chip. Well, we need to have patience till the chip is finally rolled out for the treatment purposes. The differentiation is the key to develop such a chip which would save kidney patients in future.

Wednesday, 14 June 2017

Two Part System Turns Stem Cells into Whatever You Want

Well, the science and technology has taken the world to a different level. Each day we are embraced with a new kind of discovery and invention. This has made our lives more safe and comfortable. We are now living our dreams and a much better life with reduced tensions. Recently, by using the embryonic or stem cells which are adult were used to change the target cell for reproduction. However, it is now as easy as the process is thought to be. To make things easy, a team comprised of international scientist have indulged themselves in this development. They have developed a two-part system which is able to covert the stem cells to the targets and then have the remnants removed. So only the required DNA is left behind in order to replicate.


There are few complexities with the process as it involves a bit of hard work and perfection. The human pluripotent stem cells can’t be used directly so this is a great disadvantage. This type of cells can mutate to any kind of cells within the human body. But this series of change is a bit complex which the DNA controls, once it gets triggered. In the past, many processes were followed but there were remains of the DNA as usual. So the process is bit complicated and it takes a good amount of time for the scientists.

Due to patience of the scientists, we are able to witness all these wonderful discoveries and inventions which have shaped our life in a great deal. The current method has a change as the DNA in this method is used to turn the colour of the cell green with the usage of blue light. This makes the conclusion that the plasmid of the DNA is placed in the body of the cell and it gets removed completely.


Well, there are many fields to explore in this world and hence the scientists are doing the same. They are trying their best to go beyond the limits and the effect of conversions after the DNA is removed. The earlier methods took into consideration the DNA to switch the conversions but it was not successful in removing the DNA completely that was placed inside. The new method is somewhat a bit different and it helps in removing the DNA completely. This makes the work or the process function completely and successfully.


The researchers have devoted a lot of time for this and they are currently completing the process with the help of a system known as Tet-On 3G inducible PiggyBac which is basically a plasmid that has been named XLone in order to get the objectives done.

The basic objectives are inserting, activating and removing of the DNA. The system Tet-On 3G inducible PiggyBac takes into consideration to insert the DNA into the DNA of the Cell. With information containing the correct signalling, the Tet-On 3G inducible PiggyBac system allows the stem cells to become sensitive when doxycycline is used to activate the process.