Showing posts with label colon cancer. Show all posts
Showing posts with label colon cancer. Show all posts

Saturday, 1 July 2017

Grape-Based Compounds Kill Colon Cancer Stem Cells in Mice


Resveratrol – Grape Seed Extract – Treatment of Colon Cancer


As per a team of researchers, compounds from grapes could destroy Colon Cancer stem cells in a petri dish as well as in mice. Resveratrol, the compound that is found in grape skins as well as seed could ultimately also lead to treatments of supporting in the prevention of colon cancer according to Jairam K.P. Vanamala, associate professor of food sciences, Pen State.

The second leading cause of cancer-related deaths in the U.S. is colorectal cancer as per The American Cancer Society. Vanamala, who is a faculty member at the Penn State Hershey Cancer Institute, had commented that the combination of resveratrol together with grape seed extract is said to be very effective in destroying colon cancer cells and what is learnt is that the combination of these compounds is not toxic to healthy cells.

The researchers reporting their discoveries in a recent issue of BMC Complementary and Alternative Medicine recommended that the discoveries tend to make way for clinical testing of compounds on the colon cancer of human. This is said to be the second most common cancer among women and the third in men. If it tends to be successful, the compounds could be utilised in a pill in assisting in the prevention of colon cancer as well as reduce the relapse of the ailment in colon cancer survivors.

Shotgun Approach to Cancer Prevention


Vanamala had commented that they are mainlyconcerned in aiming stem cell since as per cancer stem-cell theory, cancerous tumours are driven by cancer stem cells which are capable of self-renewal, cellular differentiation and also maintain their stem cell-like appearances even after invasion and metastasis.

According to researchers, if taken in low doses, separately, resveratrol together with grape seed extract does not seem to be as effective against cancer stem-cell suppression when they are combined together.According to Vanamala, the combined effect of grape seed extract together with resveratrol could provide clues to the reasoning of why cultures with plant-based diet seems to have lower colon cancer rates.
These diets may naturally be offering a shotgun approach to cancer prevention on utilising an extensive variety of valuable compounds to aim on numerous pathways which cancer stem cells utilise to live.

Advantageous in Promoting Bacterial Diversity


Vanamala further added that this also links well with a plant-based diet which is structured in order that the person gets a bit of diverse categories of plants, of various parts of the plant with different colours of the plant.

 According to Vanamal this could be advantageous not only in promoting bacterial diversity but also in averting chronic diseases together with eradicating the colon cancer stem cells. If the human trials tend to be successful, the compound can be taken in low doses with the prevailing available supplements for grape seed extract as well as resveratrol that are also found in wine.

But he added that there seems to be some more work to be done in order to comprehend the mechanism behind the anti-cancer properties of the grape extract together with the other colourful fruits and vegetables. More study would be focused in discovering the precise anti-cancer compounds as well as enhanced understanding on how those compounds seem to work synergistically in creating much more effective colon-cancer prevention and treatment approaches.

Friday, 12 May 2017

New Model Could Speed Up Colon Cancer Research

MIT

Colon cancer buster

Gene editing science has been an area of growth for genetic engineers and researchers across the globe. With progressing research studies, newer treatment options are being devised and successfully delivered. One such research conducted by MIT researchers have used new gene-editing systems to generate colon tumors, resembling human tumors. A new approach to a pre-existing method in genetic sciences. This paves the path for further investigation into knowledge about disease progression.

Metastases and detection:

The highest cause of death due to colon cancer is metastases, which is difficult to detect. The disease progression is so high, that fatality is hard to control even after various treatment procedures. A recent study by the director of Koch Institute, Tyler Jacks, uses similar CRISPR- based technology to build mouse models of the disease, revolutionizing research in the field of oncology.

Various approaches have been used for modeling cancer, one of them being the usage of cancer cell lines in lab dishes. This poses a lot of limitations. Another method used is mutations, which is then genetically engineered in the mice.

Recent studies involving CRISPR, which consists of DNA- cutting enzyme Cas9 and short RNA guide strands, which specialize in targeting specific genome sequences. Using the same method scientists can make targeted mutations, by either removing or adding genes. The genes for Cas9 are packaged into lentiviruses, which are then injected into target organs of the mice, transferred by colonoscopy.

What follows?

Gene editing makes this procedure possible. By virtue of which, after establishment of the tumor, mutations can be added or deleted, making the study process more complicated and informative. The information includes the aspects of metastases, initiation and progression of the tumor from liver to various parts of the body. This also helps in studying the pattern of metastases which again is peculiar in human colon.

The MIT team delivered organoids with a mutated form of the APC gene, which when established, were introduced in a mutated form of KRAS, commonly found in colon and many other cancers. These new approaches have cut short research time and has sped up the process of gene editing.

Implications:

Gene editing, this newest form of development in the field of oncology helps in drug testing, making it more successful. This ensures widening of treatment options. Factors such as age, metabolism, sex etc are also taken into consideration while conducting the study. This helps scientists choose best options for individual patients.

The mice are studied over a period of time to gain results, even though the study is supposed to be prolonged, various new discoveries and science have made it easier and faster. This helps in minimizing of side-effects post treatment and other health implications by three folds.

Genetic research shows a progressive growth over the years, showing immense scope and employment options. Diseases are getting detected sooner and treatment delivered on time. This in turn saves a lot of time, cost, manpower and patient care excels automatically.

Sunday, 11 March 2012

Risk factors associated with colorectal cancer


Risk factors for colorectal cancer include:
  •      age 50 or older
  •      history of colorectal polyps
  •      family history of colorectal cancer
  •      personal history of ovarian cancer, endometrial or breast
  •      a chronic inflammatory disease such as ulcerative colitis or Crohn's disease
  •      unhealthy diet: high in red meat and low in fiber, fruits and vegetables
  •      reduced physical activity or non-existent
If you are exposed to one of these risk factors, talk to your doctor about a screening test for colorectal cancer.

What is colorectal cancer?



The colon denotes commonly the last 6 feet (1.80 meters) of the intestines leading to the small intestine to the rectum. The colon is also known as large intestine. The last part of the large intestine is the rectum.

Colon cancer or colorectal cancer (terms used interchangeably) is a cancer of cells lining the colon. Almost all colorectal cancer cases are caused by the growth of benign polyps (noncancerous). These polyps can become cancerous and invade the colon wall and surrounding blood vessels and spread to other body parts. The symptoms are virtually unnoticed in the initial phases, while the condition is easier to treat, this is why regular screening examinations are important.