Showing posts with label diabetes. Show all posts
Showing posts with label diabetes. Show all posts

Friday, 16 June 2017

New Transplant Technology Could Benefit Patients with Type 1 Diabetes

Technology being used to cure Type 1 Diabetes

Diabetes is being noticed as a very obvious disease in people across the globe. The disease is the store house of several other diseases, and it slowly degenerates your body. The immediate consequences of diabetes may not be severe, but it has gruesome long term measures and can make you subjected to further health issues. It includes lot of restrictions in terms of food habits.

A diabetic person needs to follow a strict diet, as that would only help him to survive this serious ailment. Several approaches are being developed to free the world from this malicious disease. Many medical developments are taking place in this regard.

Approximate 1.25 million residents of America suffer from type 1 diabetes, which is also denoted as juvenile diabetes. This is disease is known for the body’s inability to generate insulin. In order to bring type 1 diabetes under control; patients are advised to test the level of glucose in their body on a frequent basis, and sometimes they are even advised to inject themselves with insulin, so that a safe balance is maintained and the body remains less prone to diseases. But some patients are reported to suffer from life-threatening consequences because of diabetes that is symptoms of hypoglycemic disorders are found.

To avoid all the fatal consequences of this ailment Garcia and collaborators along with post doctorate researchers and most importantly Jessica Weaver, is out for their venture to locate a restricting measure of diabetes. They are up for an innovative measure that would include transplantation of cells.

They are intending to develop a new hydrogel substance made of polymer, which could be easily degradable. This would be used to deliver cells through injection into the human body and it would consist of a gel based protein identified as vascular endothelial growth factor, that would result in strengthening the blood vessels into the cells transplanted in the body.

Garcia, after the experiment reported that this transplanted cells would require a lot of oxygenation and the connection to the body’s circulatory system should be high so that it grabs the sense of the level of glucose in one’s body and transport the insulin accordingly.

She has also observed that other than transporting insulin it is also capable of forming new blood vessels to nourish the existing cells. In this way, the immune syndrome of one’s body that gets shattered due to diabetes; is restored back.

Though, this measure seems innovative, yet it is not that easy as it sounds. Doctors from several decades have been trying to transplant pancreatic islets into the human body, but about 60 percent of the islets die immediately after they are transplanted because they are separated from the supply of blood while transplanting and are killed by the body’s immune response because of suddenly and directly being injected into the blood stream and fortunately those that survive, die within few months. So, the process is risky and chances of success is very less, but certainly it builds the ground for more innovations in treating type 1 diabetes.

Thursday, 10 September 2015

Blood Sugar Monitor Tested on Diabetes Patients


Blood Sugar Testing – Important for Diabetes Care

Blood sugar testing is important for diabetes care and if one tends to have diabetes, self-testing of blood sugar could be helpful in the treatment plan as well as prevent long term complications of diabetes. A blood sugar monitor which can stay in the body for up to five month is being tested on NHS patients and it is expected that the device which constantly tends to monitor the blood and provides information to a smartphone would help in controlling type 1 diabetes.

The prevailing blood sugar sensors need to be replaced weekly. People with type 1 diabetes need to prick their fingers regularly in order to test sugar levels and calculate the amount of sugar in their intakes and use this information and get themselves injected with the right amount of insulin. If the level is too high there could be damage to the body’s organs or if it is too low, it could be dangerous.

Constant Glucose Monitoring Essential

A consultant at King’s College Hospital and a lecturer at King’s College, London, Dr Pratik Choudhary, had informed BBC News website that `living with type 1 diabetes is like a bit of a blind tightrope walker and one is on this tightrope between high and low blood glucose levels and is allowed to open the blindfold four or five times a day.

Constant glucose monitoring enables the person to open the eyes and see where they are going’.The monitor developed by the US Company Senseonics is implanted under the skin in the upper arm. A fluorescent light tends to shine on the blood vessels and the amount of light reflected back is utilised in calculating the blood sugar levels that are sent to the smartphone.

A forty year old classical musician, Gwenllian Davies had been diagnosed with type 1 diabetes when she was 17 and is taking part in the experiment. She has informed that it basically controls her.

Monitor – Complete Loss of Awareness of Hypoglycaemia

When first diagnosed, one gets the rosy message that it can be controlled though it is really hard. When the blood sugar levels tend to drop to dangerous levels, she began feeling a bit shaky, with blurred vision, tingling in the lips, sweating and a feeling of sickness. She participated in the experiment since she had lost her hypo awareness and had to test how often since she did not know when she would be going low, which was the main issue.

 A constantly monitoring of glucose could be very reassuring. New NHS rules from National Institute of Health and Care Excellence states, that continuous monitor need to be offered to people with complete loss of awareness of hypoglycaemia. Dr Choudhary adds that knowing what your blood sugar is, all the time could help to gain better control. This sensor tends to last for three to five months while the other sensors in the market last only a week which needs to be taken out and changed.

Aaron Kowalski from type 1 diabetes charity JDRF who uses a continuous glucose monitor that has to be replaced every weeks states that `one of the things which is important is the proper balance between glucose control, the core of diabetes and the cost of wearing a continuous glucose monitor.

Monday, 7 September 2015

Diabetes Drug may Help in Leukaemia


Diabetes Drug Helpful in Fighting Blood Cancer

According to a research in the journal Nature, a drug used in treating diabetes could be helpful in fighting blood cancer – chronic myeloid leukaemia – CML, which is a rare kind of blood cancer. Those receiving the combination therapy would be probably free from this disease.

Around 600 individuals in the UK had been diagnosed with this condition every year. Although some successful treatments do exist, they are not helpful to every patient while some tend to be resistant to conventional therapy.

In the research, scientist provide a combination of anti-diabetic drug pioglitazone together with standard treatment to around 24 individuals whose CML was active inspite of receiving conventional drugs. Twelve months thereafter, over 50% of the individuals who were given the combination treatment were in reduction.

The first three individuals who had been given the drug showed no reoccurrences of cancer in the five years which followed. Those withuntreated CML made excessive amount of abnormal white blood cells and over a period of time, these tend to crowd over the normal white blood cells, red blood cells and platelets the person has, thus making it difficult for patients to mount a defence against infections, causing some to bleed easily.

Glitazone & Standard CML Drug – Relief for 5 Years

The present standard treatment like imatinib includes therapies. According to Cancer Research UK’s chief clinician, Prof Peter Johnson, he states, that `the outlook for people with chronic myeloid leukaemia has improved dramatically since the introduction of drugs like imatinib. However, in some patient, these drugs are not always effective.

The study is an interesting example of understanding how the biology of cancer stem cells could be helpful in improving treatment for them. But this is an early stage research and only a small number of patients have been studied. It would be interesting to see if this combination is successful in larger clinical trials’.

Others add that the side-effects of pioglitazone would have to be taken into consideration if the treatment is to be provided in routine care. Researchers observed that patients suffering from chronic myeloid leukaemia received glitazone, which is a class of drug for type 2 diabetes together with the standard CML drug imatinib were disease free for at least five years.

Gleevec – Controls Disease& Not Source of Disease

Imatinib which is commercially known as Gleevec, has a remarkable track record in controlling chronic myeloid leukaemia and enabling patients in leading a normal life. However, in spite of its effectiveness, dormant, drug resistant leukemic cells lay in wait in bone marrow and later on transform into highly destructive cells.

Gleevec tends to control the disease though cannot get rid of the source of the disease, as per chief scientific officer for the Leukemia & Lymphoma Society, who was not involved in the new research. Nonetheless adding in these glitazones, claims that one can eliminate the disease entirely according to Greenberger and these are still early days for the work.

The two well-known glitazones are Actos and Avandia. He adds that it would be ideal to run a randomized controlled trial directly comparing the effectiveness of combination therapy – imatinib and glitazone versus imatinib alone.

Patients could be treated with glitazones for months without any side effects and it would be nice to see over a period of time if the combination therapy could eliminate the disease.

Monday, 25 February 2013

Causes of Type 1 Diabetes

The exact cause of type 1 diabetes is unknown. Scientists tells that in most people with type 1 diabetes, their body's immune system - which normally fights bacteria and viruses - mistakenly destroys the insulin-producing (islet) cells in the pancreas. Genetics may play a role in this process, and exposure to certain viruses can trigger the disease. Whatever the cause, once the islet cells are destroyed, you will produce little or no insulin. Normally, the hormone insulin helps glucose get into your cells to provide energy to your muscles and tissues.

 Insulin is secreted in the pancreas, a gland located behind the stomach. When everything is working fine, once you eat, the pancreas secretes insulin into the bloodstream. As insulin circulates, it acts as key unlocking microscopic doors that allow sugar to enter body cells. Insulin lowers the blood sugar levels in the blood, and the blood sugar in the blood drops, the fact of insulin secretion by the pancreas. The liver acts as a glucose storage and manufacturing center.

When insulin levels are low and you have not eaten for some time, then the liver start to converts stored glycogen into glucose to keep your glucose level in the blood at a normal level. In type 1 diabetes, none of this happens because there is no insulin so that the glucose into the cells. Thus, instead of being transported into the cells, sugar builds up in the blood, where it can cause life-threatening complications. The cause of diabetes type 1 is different from the cause of the most familiar type 2 diabetes. In type 2diabetes, the islet cells are still functioning, but the body becomes resistant to insulin or the pancreas does not produce enough insulin, or both.

Wednesday, 20 February 2013

Symptoms of Type 1 Diabetes

Signs and symptoms of type 1 diabetes can appear quickly and may include:

 Increased thirst and frequent urination. As excess sugar builds up in the blood, fluid is pulled from your tissues. This may leave you thirsty. As a result, you may drink - and urinate - more than usual. And the following are the symptoms of type 1 diabetes

 Extreme hunger:

Without enough insulin to move sugar into the cells, your muscles and organs are depleted of energy. This triggers intense hunger that may persist even after you eat. Without insulin, the sugar in your food never reaches lack energy for your tissues.

 Weight loss:

Despite eating more than usual to relieve hunger, you may lose weight - sometimes rapidly. Without sugar supplies energy, your muscle tissues and fat stores may simply reduce.

 Fatigue: If your cells are deprived of sugar, you may become tired and irritable.

 Blurred vision:
If your blood sugar in the blood is too high, fluid may be pulled from your tissues - including the lenses of your eyes. This can affect your ability to focus clearly. Consult your doctor if you are concerned about diabetes or if you notice signs and type 1 diabetes symptoms.

Friday, 15 February 2013

What is Type 1 Diabetes?

Type1 diabetes, once referred to as juvenile diabetes or insulin-dependent diabetes, is a chronic condition in which the pancreas produces little or no insulin, a hormone necessary to allow sugar (glucose) in cells to produce the energy. Type 2 diabetes, which is much more common, occurs when the body becomes resistant to the effects of insulin or does not make enough insulin.

Various factors may contribute to type1 diabetes, including genetics and exposure to certain viruses. Although type1 diabetes usually appears during adolescence, it can develop at any age. Despite active research, type 1 diabetes cannot be cured, although it can be managed. With proper treatment, people with type 1 diabetes can expect to live longer, healthier lives than ever before.

There is nothing you could have done to prevent type 1 diabetes, there is currently no known way to prevent the disease. But researchers are working on the prevention of type 1 diabetes in people who are at high risk of developing the disease, and others working on the prevention of further destruction of pancreatic islet cells in people who are newly diagnosed. Ask your doctor if you may be eligible for one of these tests, but carefully weigh the risks and benefits of all available treatment in a clinical trial. You can find more information on the types of research from Net, a collaboration of researchers on diabetes. 

Sunday, 3 June 2012

Risk factors and related disorders of Hypertension

Several factors increase the risk of hypertension. Some of the most common factors that you can not control and that increase your risk:
  •     Age: The risk of developing hypertension increases with age. If you are over 65, you have 50% chance of being hypertensive.
  •     Ethnicity: People of South Asian descent, Aboriginal or First Nations and Inuit people of African descent have higher rates of hypertension.
  •     Family history: You have 20% chance of developing hypertension if one of your parents was hypertensive. If both your parents were affected by this disease, your chances increase to 33%.

Saturday, 17 December 2011

Flu and Its Conditions

People with certain medical conditions are at risk of flu complications. Do you suffer from diabetes, asthma, heart disease or a weakened immune system? If so, learn more about how you can protect yourself from influenza and what to do if you get the flu.

Flu and diabetes

In case of diabetes, whether type 1 or type 2, you are at increased risk of influenza complications and acute infection. For complications from influenza is defined as a hospitalization, pneumonia, respiratory distress or even death.

The flu can have several effects on your body if you suffer from diabetes:
  •     the intensity of your influenza infection may increase due to the action of diabetes on your immune system;
  •     fluctuations in your blood sugar may occur. Sometimes when you do not feel well, you do not want to eat, and it can cause a rise and a drop of your blood sugar. And the flu can increase your blood sugar.
People with diabetes are not the only high risk of influenza complications and acute infection. People with asthma, heart disease, weakened immune systems and many others suffering from chronic medical conditions are also at risk. Are you at risk of flu complications?

You can take a few provisions to protect yourself from the flu:
  •    wash your hands the right way (at least 20 seconds with soap and water) and frequently;
  •     avoid places where there are lots of people, and stay home if you think you have the flu;
  •     cough or sneeze into the crook of your elbow (not your hand!)
  •     eat healthy foods and practice regular physical exercise to strengthen your immune system;
  •     Get vaccinated. Your doctor may recommend yearly influenza vaccine and pneumococcal vaccine;
  •     control your diabetes. Take your medicine, monitor your blood sugar and follow the treatment plan recommended by your health care provider.
If you get the flu anyway, it is essential to make an appointment with your doctor as soon as you notice the first signs of flu symptoms. Do not wait until your symptoms worse. People with diabetes should schedule an appointment with their doctor immediately so that we can begin treatment. Early treatment with antiviral medication can help to reduce the risk of influenza complications. Talk to your doctor taking advantage of the Guide for the discussion with the doctor.

Wednesday, 14 September 2011

Burdock - And it treats what?

In Oriental medicine, we used the juice of burdock against appendicitis at a rate of half a glass that is recommended to drink at once. In addition, we used a decoction of seeds (10 to 20 grams per cup of water) to treat tumors of the breast or lymph gland, for diseases of the digestive tract such as stomach cramps and case of lack of vitality. We treat anemia with traditional kinpira (literally "golden peace" or "precious pieces flattened") of burdock, which is flat to cook in a skillet root cut into matchsticks. It blew up the pieces for 2 or 3 minutes in oil, add a little water and simmer until tender. It is seasoned with a little tamari sauce and baked a few more minutes, covered. Then, remove the lid and leave everything on the heat until liquid has evaporated.

European tradition has made an herb greatly appreciated, especially for its purifying qualities. Scavengers, what! It is also diaphoretic, diuretic, choleretic, diabetes, antibiotics, topical, antidotal. It has been used to treat boils, anthrax, abscesses and dental throat, dermatitis, acne, eczema, wounds, ringworm, measles, gout, rheumatism, diabetes, urinary stones and bites of vipers. Its use in cases of diabetes explained by its high inulin, a complex sugar that diabetics can learn.

Wednesday, 1 December 2010

Genetics is finally a Modern Science

Everything is genetically determined once and for all and our genes determine our health, that's what we told the old doctrine preformationism which since the seventeenth century, states that all living is already preformed in the germ and in the embryo, and that it is not subject to transformation. Since the speech has hardly changed, unfortunately ... For the truth is otherwise. This is a new science that tells us: epigenetic. It states that genes are expressed or not according to our habits, our lifestyle, our relationship with nature, our food, but also, unfortunately, many pollutants we are exposed. In summary, the epigenetic theory demonstrates the influence of environment on the functioning of genes.

One lived in town, had poor hygiene, poor health and several cancers. The other, living in the countryside, do not develop the genetic disease, however, could be programmed by the same genes. The epigenetic states that can influence gene expression without altering the genome of the individual. For example, some genes can be repressed and no longer will encode disease while others will put in operation and protect us. The former can cause cancer and prevent others. The action is not direct but depends on environmental factors that influence the proteins on which DNA is wound. Thus one can, in animals, change the color of the skin by acting on purely functional factors. This also means, unfortunately, that some chemicals that we did not know carcinogens may become inducing stimulation of genes expected to be inhibited. It is now recognized as bisphenol A, a plastic hardener now known to all, would imply a deregulation of the gene encoding adiponectin, the hormone of satiety that protects us from diabetes.

For epigenetic, nutrition plays a key protective role. One thinks, for example, that vitamins like B9, B12, provided they are natural, or certain foods like broccoli and avocado, make reversible expression of disease genes. Vitamin C blocks the expression of hereditary diseases such as Charcot-Marie-Tooth. So much the worse for those who thought it sufficient to change the picture of our genetic identity card to change our future.