Showing posts with label genome. Show all posts
Showing posts with label genome. Show all posts

Saturday, 11 March 2017

This AI Doctor Knows What's Wrong With You By Checking Your Genome

Genome

Sequencing of Genome – Decoding DNA

A Swiss based Sophia Genetics, Camblong has been attempting the possibility to democratise data driven medicine by standardising the data analytics all across the globe. Initiated in 2011 it has been trying to do the same with the help of artificial intelligence together with machine learning. Speaking at the conference of Wired Health, in London, Jurgi Camblong had announced that within the following few weeks the firm would be analysing the genomic profiles of 100,000 people.

The sequencing of genome is said to be the practice of decoding the DNA of a person which is a procedure that tends to generate massive extent of data. Each person’s genome comprises of 3.2 billion letters of DNA containing around 20,000 separate genes. The genomic program at NHS has been focusing to sequence 100,000 genomes all over England, wherein beginning of March, it had completed 20,000. On completion, it stated that the data would come in at 31 petabytes.

 In order to get an understanding of the scale, one petabyte of music would be taking about 2,000 years to play. In his firm’s SOPHiA artificial intelligence, which tend to learn from the genomic profiles of patients, Camblong had mentioned that it had already been utilised in supporting the diagnosis of 100,000 people.

AI – Hospitals Receives Actionable Insight

By utilising the AI, hospitals have been capable of receiving `actionable insight regarding patients which enables doctors in comprehending the cause regarding the diseases. It has been mentioned by Sophia Genetics that it has been operating on five areas namely oncology, hereditary cancer, cardiology, metabolism and paediatric conditions.

Camblong had informed that the more data SOPHiA tends to process, it learns more, since information is constantly shared secretly on the platform in order to assist clinicians to enhance individually thus making improved decisions. The scheme tends to function by observing the genomic profiles of each individual, combing it with the information of doctors as well as clinicians.

With the help of machine learning, the more date system is fed, the better is the decision it tends to make. The business model tends to work by charging the hospital every time it utilises the tool. Camblong debates it is so because his firm is capable of computing data better than the hospitals it sells to.

Future - Chronic Disorder

Presently the software of the company is being utilised in around 250 hospitals in 45 countries all over the world which comprises of 10 NHS hospitals in the UK. This is said to be twice the number of hospitals which had been utilising the software beginning of 2016 according to Camblong’s information to WIRED. Neither the firm nor the NHS is the only one interested in processing genomic sequencing.

 Google in the earlier years had been approaching hospitals as well as universities, proposing them its cloud services in order to store genome data in the cloud. The cost presently is around £1,000 in order to sequence the genome of a complete person. However, when it had first sequenced in 2000 the cost was about $100 million.
According to Camblong, the downward trend would continue as the amount of data and knowledge will increase and in time that cost would drop to $100.Camblong is of the belief that in the near future, cancer would be considered as a `chronic disorder and hopes that it would be possible to look at this disease and say that it looks like the cancer of 10,000 other patients’, providing advice to doctors for the treatment of the same.

Wednesday, 1 December 2010

Genetics is finally a Modern Science



Everything is genetically determined once and for all and our genes determine our health, that's what we told the old doctrine preformationism which since the seventeenth century, states that all living is already preformed in the germ and in the embryo, and that it is not subject to transformation. Since the speech has hardly changed, unfortunately ... For the truth is otherwise. This is a new science that tells us: epigenetic. It states that genes are expressed or not according to our habits, our lifestyle, our relationship with nature, our food, but also, unfortunately, many pollutants we are exposed. In summary, the epigenetic theory demonstrates the influence of environment on the functioning of genes.

One lived in town, had poor hygiene, poor health and several cancers. The other, living in the countryside, do not develop the genetic disease, however, could be programmed by the same genes. The epigenetic states that can influence gene expression without altering the genome of the individual. For example, some genes can be repressed and no longer will encode disease while others will put in operation and protect us. The former can cause cancer and prevent others. The action is not direct but depends on environmental factors that influence the proteins on which DNA is wound. Thus one can, in animals, change the color of the skin by acting on purely functional factors. This also means, unfortunately, that some chemicals that we did not know carcinogens may become inducing stimulation of genes expected to be inhibited. It is now recognized as bisphenol A, a plastic hardener now known to all, would imply a deregulation of the gene encoding adiponectin, the hormone of satiety that protects us from diabetes.

For epigenetic, nutrition plays a key protective role. One thinks, for example, that vitamins like B9, B12, provided they are natural, or certain foods like broccoli and avocado, make reversible expression of disease genes. Vitamin C blocks the expression of hereditary diseases such as Charcot-Marie-Tooth. So much the worse for those who thought it sufficient to change the picture of our genetic identity card to change our future.