Showing posts with label health news. Show all posts
Showing posts with label health news. Show all posts

Monday, 25 September 2017

One Vaccine Injection Could Carry Many Doses

Library of Tiny/Encased Vaccine Particles

 
An innovative 3-D fabrication system has been designed by the MIT engineers that tend to generate a novel kind of drug-carrying particle enabling various doses of a drug or vaccines to be provided over an extended time period with only an injection.

 The innovative micro particles are said to be made of biocompatible, FDA approved polymer that can be considered to degrade at specific times, spilling out the contents of the `cup’. Robert Langer, the David H Koch Institute Professor at MIT had commented that they are excited regarding this work since for the first time they can create a library of tiny, encased vaccines particles wherein each are programmed to release at an accurate, predictable time in order that individuals could probably receive a single injection which in effect would tend to have several boosters that are built in it already.

This could have a substantial influence on the victims everywhere particularly in the developing world where the person’s compliance seems to be at the lowest. A research scientist at MIT’s Koch Institute for Integrative Cancer Research, Ana Jaklenec and Langer are the senior authors of the paper which appeared online in Science on Sept 14.
 

Several Doses of Vaccines/One Injection

 
The lead authors of the paper are postdoc Kevin McHugh and earlier postdoc Thanh D. Nguyen presently an assistant professor of mechanical engineering at the University of Connecticut. As part of a project subsidized by the Bill and Melinda Gates Foundation, Langer’s lab started working on the innovative drug delivery particles that was looking for means of delivering several doses of vaccines over specified period to time with only one injection.

This would enable babies in developing nations who may not see a doctor often to get one injection after birth which would deliver all of the vaccines they would need during the first one or two years of life. Langer had earlier developed polymer particles with drugs implanted all over the particle enabling them to be gradually released over a period of time. But the researchers needed to come up with a way to deliver short burst of a drug at particular intervals, for the project to mimic the manner in which a series of vaccines could be administered.
 

PLGA – Biocompatible Polymer

 
In order to accomplish their goal on drug or vaccines, they started to cultivate a sealable polymer cup made from PLGA that is a biocompatible polymer which had been already approved for usage in medical devices like the implants, sutures as well as prosthetic devices.

It is said that PLGA could also be intended in degrading at various rates enabling for fabrication of numerous particles which tend to release their contents at various times. Conservative 3-D printing techniques is said to incompatible for the material as well as the dimension which the researchers needed and hence they had to create a new method of fabricating the cups gaining inspiration from computer chip manufacturing.

They developed silicon molds for the cups as well as the lids utilising the photolithography. Huge selections of around 2,000 molds are placed on a glass slide wherein these are utilised in shaping the PLGA cups (cups with edge lengths of some hundred microns) and lids. The researchers had engaged a custom-built, automated dispensing method of filling each cup and the system was heated slightly till the cup and lid fused together, sealing the drug within, when the selection of polymer cups had been shaped.
 

StampED Assembly of Polymer Layers

 
Jaklenec had stated that every layer is fabricated at first on its own and thereafter assembled together. Part of the novelty is really in how they align and seal the layers. By doing so they developed a new system which could make structures that current 3-D printing methods are unable to do. The latest system is known as SEAL – StampED Assembly of polymer Layers, and can be utilised with any thermoplastic material enabling fabrication of microstructures with complex geometries that tend to have broad application comprising of injectable pulsatile drug delivery, pH sensors together with 3-D microfluidic devices.

An assistant professor of mechanical engineering and biomedical engineering at Vanderbilt University, Leon Bellan stated that the approach tends to provide an impressive amount of control in constructing 3-D micro particles. Bellan who had not been involved in the study stated that it seems to be a new take on 3-D printing procedure as well as an elegant solution in building macroscopic 3-D structures out of material which are relevant for biomedical application.

The molecular weight of the PLGA polymer together with the backbone structure of the polymer molecule tends to regulate how quick the particles could degrade after the vaccines. The rate of degradation determines when the drug would be released and on injecting several particles which degrade at varied rates, the researcher could create a strong burst of drug or vaccines at predetermined time point.
 

Vaccines in One Shot

 
McHugh had stated that in the developing world that could be the variance between not getting vaccinated and receiving all of the vaccines in one shot. The researchers showed that in mice, particle release in sharp bursts without previous leakage was at 9, 20 and 41 days after the injection. Thereafter they examined particles that were filled with ovalbumin, which is a protein that is found in egg whites and is generally utilised to experimentally motivate an immune response.

Utilising a mixture of particles which tend to release ovalbumin at 9 and 41 day after injection they discovered that a particular injection of these particles had the capabilities of inducing a strong immune response which was equivalent to that triggered by two conservative injections with twice the dose. Besides this, the researchers also designed particles which could degrade as well as release hundreds of days after the injection.

 The researcher state that one experiment of developing long-term vaccine based on these particles is of ensuring that the encapsulated drug or vaccines tends to be stable at body temperature for a long time before being released. They now intend to test these delivery particles with various drugs comprising of prevailing vaccines like inactivated polio vaccine together with fresh vaccines which are in the development stage. Moreover they are also working on plans of stabilizing the vaccines.

The researchers have also designed particles that can degrade and release hundreds of days after injection. One challenge to developing long-term vaccines based on such particles, the researchers say, is making sure that the encapsulated drug or vaccine remains stable at body temperature for a long period before being released. They are now testing these delivery particles with a variety of drugs, including existing vaccines, such as inactivated polio vaccine, and new vaccines still in development. They are also working on strategies to stabilize the vaccines.

“The SEAL technique could provide a new platform that can create nearly any tiny, fillable object with nearly any material, which could provide unprecedented opportunities in manufacturing in medicine and other areas,” Langer says. These particles could also be useful for delivering drugs that have to be given on a regular basis, such as allergy shots, to minimize the number of injections.

Other authors on the paper are Allison Linehan, David Yang, Adam Behrens, Sviatlana Rose, Zachary Tochka, Stephanie Tzeng, James Norman, Aaron Anselmo, Xian Xu, Stephanie Tomasic, Matthew Taylor, Jennifer Lu, and Rohiverth Guarecuco.

Friday, 22 September 2017

As 'Flesh-Eating' Leishmania Come Closer, a Vaccine Against Them Does, Too

Leishmania – Second-Deadliest Parasite in the World

 
Parasites which affect the skin and can mutilate the face; tend to seriously damage the internal organs, have been coming nearer to the southern edges of the United States. Though no vaccines are available against Leishmania, researchers have almost come close in bringing about a change.

 An innovative experimental vaccine complete with proprietary biological particles established at the Georgia Institute of Technology tends to have immunized laboratory mice which had been genetically changed to imitate the human immune system. As per a new research, the vaccine is said to exploit a weakness which the tricky chemical mask in Leishmania tends to generally hide from the disease fighting cells of the victim to activate a forceful immune response against the parasite.

According to the World Health Organization, Leishmania is said to be the second-deadliest parasite in the world surpassed only by malaria. There are around 30 strains of Leishmania. They are said to be transmitted mostly through the bit of a phlebotomine sand fly that tends to feed on the blood. The global warming has been expanding the potential habitat of the insect towards the north of Latin America. The epidemic regions nearest to the United States of leishmaniasis, the disease affected by the parasite has come now almost to 300 miles of the border.
 

Leishmania –Different Symptoms

 
With those who contract Leishmania, the parasite is said to cultivate leishmaniasis and the disease tends to have different symptoms or probably also shows no outwards indication of the disease. However when it tends to break out, it could cause grave skin boils as well as some types of severely eat away at the nose and lips and also removal of some parts of them. If another type of the parasite tends to get into the bloodstream it could also injure the liver as well as the spleen in the most dangerous way of the disease known as the visceral leishmaniasis which is also called black fever.

A professor in the parasitology department of the Universidade Federal de Minas Gerais in Brazil and also one of the lead researchers on the new experimental vaccine, Alexandre Marques had commented that `if it is not treated within 20 to 40 days, visceral leishmaniasis often tends to kill the victim’. However conventional treatment generally effective could leave small numbers of the parasite that could lead to relapse in the patient or act as a carrier in a likewise manner as in the case of malaria. A vaccine would prove to be helpful in preventing epidemics.

Leishmania are said to be single-cell organisms which are the size of large bacteria that have been a menace in around 90 countries in South America, the Middle East, Africa and Asia together with southern Europe. Researchers have been working to discover a vaccine against them and identical parasites with much success for years.

 M. G. Finn leading the work on the new vaccine had commented that in comparison to viruses and bacteria, there seems to be much more complex organisms and more tough to crack. Finn is said to be a professor in Georgia Tech’s School of Biological Sciences and in the School of Chemistry and Biochemistry which he also heads.

The innovative vaccine leverages intimate knowledge which the team of Marques had obtain living as well as working on the edge of leishmaniasis epidemics areas. Finn had informed that one of the students of Marques, Alex had gathered the sand flies and then extracted the parasites in the lab to do complex mass spectrometry together with the other tests to research the molecular makeup in impressive detail. The team had discovered minute details on the exterior surface of Leishmania which tends to make it susceptible to human immune reaction.
 

New Vaccine Employs Fake Virus

 
The prospective of the new vaccine, designed at Georgia Tech tends to employ a fake virus as an inducement to draw major immune systems forces to these faults to attack them. The replica virus or virus-like particles does not seem to be infectious and the body terminates it after usage. Several variations of such particles in recent years had been developed at the lab of Finn together with other products comprising of the same have already been through phase II human clinical trials.

The results of their vaccination development as well as testing had been published by Marques and Finn on September 13, 2017 in the journal ACS Central Science. It is said that the research had been financed by the National Institutes of Health, Children’s Healthcare of Atlanta as well as Brazil’s National council for Scientific and Technological Development. The following queries and answers would be beneficial in comprehending how the vaccine could influence the chemical facade of Leishmania:

What is so tricky regarding chemical fa├žade of Leishmania?

The parasites are said to cover themselves in carbohydrates that seem like food and also tend to cover the other cells in the body. To the body, the Leishmania cells seem inoffensive and the immune system has a tendency to leave them alone.

What is the crack in the facade? 

Some of these carbohydrates tend to truly generate a mild human immune response which is not adequately strong to actually combat Leishmaniasis. However it gave Marques and Finn’s vaccine some headway. It is fortunate that humans as well as some other primates tend to have this precise immune reaction, since the other mammals do not and hence this vaccine would not work on them. To test the new vaccine, the laboratory mice had to be genetically changed to make their immune system react to the carbohydrates the way it tends to do for humans.

How does the fake virus tend to function? 

Finn had informed that they used the virus-like particles to enhance a key carbohydrate on the surface of Leishmania clearly to the body. This tends to persuade its immune system in reacting strongly against it like a foreign structure.

The immune system tends to go after the false virus like guard dogs after an intruder. The researchers had attacked the odd carbohydrate to the false virus which made the immune system recognize that carbohydrate as a severe risk. Immune cells then hunt it down and in this process tend to eliminate the parasite which creates it.

Saturday, 16 September 2017

Pen Identifies Cancer in 10 Seconds

Pen

The MasSpec Pen – Device of Identifying Cancerous Tissue

As per scientist at the University of Texas, a handheld device has the potential of identifying cancerous tissue in a matter of 10 seconds. It is said that it could enable surgery in removing a tumour much quicker, safer with accuracy. It is likely that it would save on any anguish of leaving traces of cancer behind. The experiments published in Science Translational Medicine have recommended that the technology tends to be 96% precise.

 The MasSpec Pen is said to take the benefit of the exclusive metabolism of cancer cells. Their frantic drive to develop and spread would mean that their internal chemistry could be different to that of healthy tissue. It operates when the pen is touched to a suspected cancer area and then releases a tiny droplet of water. The chemicals within the living cells is said to transfer into the droplet wherein it is then sucked back up to the pen for analysis.

The pen is said to be plugged in a mass spectrometer which is a bit of a kit that has the capability of measuring the mass of thousands of chemicals each second. It is said to create chemical fingerprint which informs doctors if they are looking at healthy tissue or cancer. 
 

Challenge – Border Between Cancer & Common Tissue

 
Surgeons are faced with the challenge of locating the border between the cancer and common tissue. It tends to be clear in some tumours though in case of others, the boundary seems to be unclear between healthy and diseased tissue. This device could be helpful to doctors in ensuring that no trace of the cancer is left behind in the patient.

The removal of too little tissue and any trace of cancerous cells could develop into another tumour. However taking too much could cause damage, especially in cases of organs like the brain. Assistant professor of chemistry, Livia Eberlin, at the University of Texas, Austin, had informed BBC that `what’s exciting about this technology is how clearly it meets a clinical need. The tool is sophisticated and simple and can be in the hands of surgeons in a short time’. As part of the research, the technology had been verified on 253 samples and the intention is to continue verifying in order to refine the device before conducting tests during operation next year.
 

Modern Endeavour of Improving Precision of Surgery

 

The pen presently is said to examine a patch of tissue 1.5mm across though the researchers have developed pens already which seems to be more advanced and are capable of looking at improved area of tissue just 0.6mm across. The mass spectrometer is said to be costly and large though the pen is quite economical. The MasSpec Pen is considered to be the modern endeavour of improving the precision of surgery.

A team at Imperial College London is said to have created a knife which tends to smell the tissue it cuts in order to define whether it is eliminating cancer. Another team at Harvard have been utilising lasers in analysing how much of a brain cancer can be removed. From Cancer Research UK, Dr Aine McCarthy had stated that `exciting research such as this tends to have the possibility of speeding up on how doctors can determine if a tumour could be cancerous or not and be aware of its characteristics.

Saturday, 1 July 2017

Grape-Based Compounds Kill Colon Cancer Stem Cells in Mice


Resveratrol – Grape Seed Extract – Treatment of Colon Cancer


As per a team of researchers, compounds from grapes could destroy Colon Cancer stem cells in a petri dish as well as in mice. Resveratrol, the compound that is found in grape skins as well as seed could ultimately also lead to treatments of supporting in the prevention of colon cancer according to Jairam K.P. Vanamala, associate professor of food sciences, Pen State.

The second leading cause of cancer-related deaths in the U.S. is colorectal cancer as per The American Cancer Society. Vanamala, who is a faculty member at the Penn State Hershey Cancer Institute, had commented that the combination of resveratrol together with grape seed extract is said to be very effective in destroying colon cancer cells and what is learnt is that the combination of these compounds is not toxic to healthy cells.

The researchers reporting their discoveries in a recent issue of BMC Complementary and Alternative Medicine recommended that the discoveries tend to make way for clinical testing of compounds on the colon cancer of human. This is said to be the second most common cancer among women and the third in men. If it tends to be successful, the compounds could be utilised in a pill in assisting in the prevention of colon cancer as well as reduce the relapse of the ailment in colon cancer survivors.

Shotgun Approach to Cancer Prevention


Vanamala had commented that they are mainlyconcerned in aiming stem cell since as per cancer stem-cell theory, cancerous tumours are driven by cancer stem cells which are capable of self-renewal, cellular differentiation and also maintain their stem cell-like appearances even after invasion and metastasis.

According to researchers, if taken in low doses, separately, resveratrol together with grape seed extract does not seem to be as effective against cancer stem-cell suppression when they are combined together.According to Vanamala, the combined effect of grape seed extract together with resveratrol could provide clues to the reasoning of why cultures with plant-based diet seems to have lower colon cancer rates.
These diets may naturally be offering a shotgun approach to cancer prevention on utilising an extensive variety of valuable compounds to aim on numerous pathways which cancer stem cells utilise to live.

Advantageous in Promoting Bacterial Diversity


Vanamala further added that this also links well with a plant-based diet which is structured in order that the person gets a bit of diverse categories of plants, of various parts of the plant with different colours of the plant.

 According to Vanamal this could be advantageous not only in promoting bacterial diversity but also in averting chronic diseases together with eradicating the colon cancer stem cells. If the human trials tend to be successful, the compound can be taken in low doses with the prevailing available supplements for grape seed extract as well as resveratrol that are also found in wine.

But he added that there seems to be some more work to be done in order to comprehend the mechanism behind the anti-cancer properties of the grape extract together with the other colourful fruits and vegetables. More study would be focused in discovering the precise anti-cancer compounds as well as enhanced understanding on how those compounds seem to work synergistically in creating much more effective colon-cancer prevention and treatment approaches.

Wednesday, 28 June 2017

Apollo Mission to Drive Therapeutic Innovation

Therapeutic Innovation
Image Credit:Taema

Age of Mounting Biomedical Invention


 Stimulations of a rebellion has given way through hundreds of laboratories which are aiming to cause new medicines that will be faster with less disappointments. This is being led by three UK universities together with three global pharmaceutical corporations. A four strong team has over the past year indulged in hundred meetings with scientist at three UK universities and towards the end of this year would probably tend to have another hundreds of such meetings.

They have been storing the maximum complete sense of what tends to occur at the bench across the three UK universities namely Cambridge, Imperial College London and University College London – UCL, which anyone had ever accumulated. Their task is to detect research which seems to have the greatest possibility of making it all the way through in being a new medicine and thereafter in supporting it to occur.

The team headed by Dr Richard Butt has explained that the drive behind their meetings are that they tend to live in an age of rapidly mounting biomedical invention, an age where the development of new medicine needs to be at an all-time high though the number of new drugs that are developed seems to be largely static.

 Valley of Death


  The time between getting promising results in an academic lab, in drug discovery, and receiving real interest from an investor or pharmaceutical corporation seems to be known as the `Valley of Death’ and with a good reason. Discerning as well as developing likely new medicines needs not only money but also knowledge together with quick delivery of industrial-kind science.

Several of the drug patients tend to succumb along the way before it is known whether they have fulfilled an unmet remedial requirement. The tech transfer offices – TTOs of Cambridge, Imperial College and UCL, had joined forces with three global pharmaceutical corporations, AstraZeneca (AZ) GSK and Johnson & Johnson, in January 2016, to develop a £40m collaboration known as Apollo Therapeutics.

According to Butt, their focus was in streamlining the academia-to-industry pipeline by discovering the best translatable science funding it fast and running the right development programme in making it appealing to industry. Apollo in consequence, tends to focus in maximising the opportunity wherein a probable drug would be developed from emerging basic science on investment of a state-of-the-art drug discovery programme which pharma company would find it appealing to license.

  Apollo Approach – New & Revolutionary


  Dr Iain Thomas, head of Life Sciences of Cambridge Enterprise – Cambridge’s TTP has commented that the Apollo approach is completely new and revolutionary. One could say that Apollo is building reassurance and the hardest part of the job at Cambridge Enterprise is selling good technology to pharma.

It relates to the psychology of buying and people do not tend to purchase complicated stuff with plenty of risks without much scrutiny. Guarantee tends to come in from being engaged with an opportunity for a long time. Partnership and engagement seems to be at the heart of the Apollo model.

Initially, Butt’s team spoke to the academics and TTOs of the universities in recognizing thrilling predictions before taking some of the ideas to the wider team of investors, comprising of the three companies together with the TTOs. He commented that as scientists, they would always be happy in spending time engaging in discussion with any academic regarding their job. He added that as drug discoverers, they had been very particular on what to take forward. They have filtered aggressively to maximise the opportunity of success.

  Goal – Finding New Medicines for Patients


  Apollo and the academics would work together, once a project has been designated for investment, to develop the discovery to a phase which will be appealing to a company to license and then take it ahead. This labour could occur in the laboratory of academic or in one of the Pharma Corporation or in a contract company. Moreover it could also take place at the Milner Therapeutics Institute, research laboratories which would open on the Cambridge Biomedical Campus towards 2018 devoted to adopting close combined connections between academia and industry.

Dr Ian Tomlinson, Chair of Apollo had informed that the significant is bringing together the skill sets, philosophies together with expertise of those who discover with those who know what to do with that discovery and that they are all motivated by the goal of finding new medicines for patients.

 He further added that the conventional pipeline functions thus – an academic does some great science, takes it as far as they are capable to within the limits of the lab and thereafter if they need to take it further, it either forms a spin-out or licenses to pharma.

 This tends to have its place though it would take time and is expensive. If the team of Richard tends to bring the investment team with a good idea, Apollo could fund it and be working with the academic within a few weeks.

  Drug Improvement Programme


  Amidst the Butt and his three colleagues they have more than 60 years of experience in the pharma industry. He informed that they saw the boom of the late 80s/early 90s of drug approvals and then genomics, high-throughput screening together with a seeming wealth of targets led to the mind-set of `we can scale this success’ – if we run thrice more projects and be three times more successful.

The basic biology nearly ended to matter. Projects seem to run which should not have been and R&D costs mounted though the output of new drugs flat-lined or even dropped. His team has already recognized eight projects all over the three universities to receive Apollo subsidy.

The first to be supported originated from a 20-year search by Dr Ravi Mahadeva at Cambridge’s Department of Medicine to treat Alpha-1 trypsin deficiency – AATD, for a small molecule drug. AAT is said to be a protein which usually protects the lungs and in AATD, a single genetic mutation causes it to aggregate in the liver. The outcome affects the liver and lungs are disabling leading to serious problems.

Presently there is no effective long-term treatment for this ailment. Apollo funds, for professor Randall Johnson, has meant that his research in Cambridge’s Department of Physiology, Development and Neuroscience tends to have been constant effortlessly through a drug improvement programme without the need of stop-start of waiting for subsidy, licensing or creation of a spin-out.

Wednesday, 21 June 2017

Science without borders is needed to solve the mystery of Alzheimer’s disease

Alzheimer’s disease
Alzheimer’s Disease & Related Disorders

Unpublished research at Symposium developed to fast-track prevention, together with treatment as well as cure for the unbearable disease affecting 1 in 3 seniors has been shared by 16 of the top Alzheimer’s scientists of the world.

Dean of the Keck School of Medicine of USC, Rohit Varma had welcomed the elite group to the 4th annual Zilkha symposium on Alzheimer Disease & Related Disorders. Varma had stated that he is delighted to host this conference that tends to bring together the best and the brightest physician-scientists from across the globe for studying new, basic, translational as well as clinical efforts in the field of Alzheimer’s and related neurodegenerative disorders.

He expects that with their wisdom, insight together with hard work they would put an end to the menace of this disease. Rudolph Tanzi of Harvard University, David Holtzman – Washington University, John Trojanowski and Virginia Man-Yee Lee - University of Pennsylvania, Kaj Blennow – University of Gothenburg in Sweden, Roger Nitsche – University of Zurich, Christer Betsholtz – Uppsala Universitet in Sweden and Ronald Petersen – Mayo Clinic college of Medicine are said to be some of the researchers that have joined Keck School of Medicine scientists Berislav Zlokovic and Paul Aisen in presenting their new discoveries.

Symptoms – 15 Years After Sticky Amyloid Proteins – Dull the Brain

According to Aisen, director of the USC Alzheimer’s Therapeutic Research Institute that leads eight clinical trials on the disease, states that the symptoms of Alzheimer’s tends to appear around 15 years after sticky amyloid proteins seem to dull the brain.

Quoting data from the on-going Alzheimer’s Disease Neuroimaging Initiative study, Aisen had informed that around 80% of the participants having amyloid deposits in their brain but no symptoms of Alzheimer’s have developed symptoms of the disease within the next nine years.

Relatively only about 20% of the people devoid of amyloid deposits had later on developed related symptoms. He further added that he was of the opinion that they needed to carry this study further till they would feel that almost everyone with elevated amyloid would progress to symptomatic AD.

 Moreover it seemed reasonable to anticipate that they tend to start the trashy of anti-amyloid, 15 years prior to the expected onset of symptoms, they would be capable of preventing the development of clinical Alzheimer’s disease. In order to the trace the development of the disease over a period of time, Aisen has been enrolling healthy individuals having no symptoms of Alzheimer’s in clinical studies.

Biomarkers in Blood

In comprehending the disease and its progress would assist in the development of a `liquid bipsy’ blood test which would bring about an insight to the doctors wherein individuals could be at high risk for Alzheimer’s. In future, once the doctors tend to identify that a patient has early build-up of amyloid, they will be capable of prescribing a drug that could destroy the same.

 Thereafter, individuals could take a drug like a BACE- inhibitor in order to prevent amyloid build-up according to Aisen. Aisen had also added that doctors will ultimately be in a position of identifying people likely to develop Alzheimer’s through biomarkers found in blood draws, which will simplify preventive treatment. Director of the Zilkha Neurogenetic Institute, Zlokovic had challenged the amyloid hypothesis of Aisen stating that amyloid is not ground zero for neurodegeneration.

Zlokovic had commented that he is a bit worried if they consider Alzheimer’s is exclusively amyloid-derived neurodegeneration. He would state that this is a very complex, multifactorial disease which is motivated by genetic, vascular and environmental factors that all can effect disease inception and progression. He further added that disease inception may or may not include amyloid at all.

Healthy Brain – Healthy Blood Vessels

He explained that according to latest studies, issues in brain circulation like subtle damage to the smallest brain vessels, capillaries, loss of cerebrovascular integrity as well as blood flow changes taking place early could be vital to disease progression and lead to amyloid and tau pathology.

Zlokovic has been performing pioneering research on how leaks in the vascular system of the brain, the blood-brain barrier, tend to cause a flow of issues, inclusive of amyloid build-up. Zlokovic had mentioned that health epidemic of the 21st century is age-linked small vessel disease of the brain. Small vessel disease is said to contribute to around 45% of all dementias all over the world including Alzheimer’s.

Zlokovic recently had installed as the Mary Hayley and Selim Zilkha Chair in Alzhemier’s Disease Research further commented that a healthy brain needs healthy blood vessels. The blood-brain barrier averts the entry into the brain of blood deprived toxic products, pathogens and cells. Over 70 USC researchers over a range of disciplines have been inspecting the health, societal as well as political effects and its implications of Alzheimer’s.

 Zlokovic had informed that they would be looking forward to hosting this symposium again the next year and that it is critical for top experts of Alzheimer’s to come together and share their unpublished discoveries, concept and state-of-the art approaches in order that scientific barriers are eliminated and all tend to work together in arresting and reversing this devastating disease.

Monday, 19 June 2017

Human Stem Cells Model the Kidney Filtration Barrier

Glomerular filtration chip devised by the human stem cells differentiation

Well, it is a relief for the ailing ones especially the kidney patients. The glomerular filtration is the new addition in terms of the kidney related diseases. The best part is that a new chip has been designed which consists of the glomerulus itself and it could bring a smile for the kidney affected persons. The therapeutic therapy has been given a new dimension post this chip manufacturing.

The kidney is one of the most important organ in our body. It is quite essential and performs a lot of functions for our body. The filtering of blood is the most important one and also helps in removing waste elements via urine. It retains the elements in the form of proteins in our body which is beneficial for the circulation of blood and proper metabolism of the body.

THE STRUCTURE

The main thing that helps in achieving all the above mentioned activities is none other than the glomerulus itself. There is a membrane which is thin and separates the matrix. It filters the material. The researches go on in every field. The medical field is no exception. We had recently some of the greatest discoveries in the medical arena. It has really got advanced and helped to cut down the mortality rate by a huge margin by inventing new drugs or machines.

This has been possible with the combination of science and technology which has revolutionised the world. The stem cells were under the microscope for a long time which can convert to podocytes. These can be really very helpful for the medical field. Well, the glomerular filtration was not successful when podocytes were taken into consideration in order to culture cells.

THE SOLUTION

Where there is a way, there is a will. Well, certainly there is and nothing is impossible in this digital world. The solution was figured out by the scientists and developers for the glomerular filtration. The new process is something different where the podocytes which are considered to be mature are formed by separating the stem cells of human which have been induced by pluripotent.

THE WORKING

And it works as a wonder as the success rate is close to 90 percent. Now these were embedded on a chip and a model of the glomerulus of the human as created. In this fashion, the filtration process reached a new height and all the proteins and toxic elements could be differentiated. This chip which has been developed by the researchers will play a promising role in the near future.

This will also play a key role for more research in terms of experiments and other tests. The aspect of biology will get broader and widened now a bit with the development of the glomerular filtration chip. Well, we need to have patience till the chip is finally rolled out for the treatment purposes. The differentiation is the key to develop such a chip which would save kidney patients in future.

Monday, 12 June 2017

Zika Transmitting Mosquitoes have Resistance to Commonly Used Insecticides

Mosquitoes
The world has witnessed some of the greatest virus that has taken a huge number of lives. The countries of Africa are the worst affected. To help them, the WHO has come forward but when it comes for a new type for virus like the ZIKA or the DENGUE, the WHO has also failed. We were only allowed to stay in dark. But recently a renowned professor from The Institute of Environmental and Human Health (TIEHH) at Texas Tech University has stated that there is high possibility that the world would be shaken by the outbreak of ZIKA virus. The person himself is not sure where the breakout may be. He believes it can be in States or it can be in any isolated place. But whatever may be in the future, he is ready to fight with all resources.

THE RESOURCES

He has decided to start the most important research and for this he is getting funded by whooping amount of $2000000 from the Texas Department of State Health Services. The main objective is to get the knowledge of the mosquito insecticides and its effectiveness for which it has been used against the ZIKA virus and other dangerous diseases. The primary objective is to eliminate the virus as it has already taken a huge number of lives. So, it has to be stopped before another outbreak creates a chaos in the world. If not eliminate them, the virus has to be controlled in the most efficient manner. This would help in preventing the spreading of the virus. For the researchers, the baffling question is whether the virus is resistant to mosquito insecticides. If they are resistant to mosquito insecticides, then it is a great matter of concern.

THE TESTS

Presley, who has already tested the ZIKA outbreak much before the U.S. House of Representatives Committee on Science, Space and Technology in May 2016, has been a part of the committee who has been working for bringing mosquito diseases under control and the transmission of disease. They have been working very hard in order to restore the momentum but it has only got worse.

EXPECTATIONS

However, the time will decide whether the virus have become resistant to the mosquito insecticides. They have been used in the state of Texas and the reports would reveal everything. So, we need to keep our patience as this is a major concern in terms of health and immunity all over the world. If the reports are positive, then it would be very helpful to combat the dangerous effect and threat of the ZIKA virus.

PREVENTION

Brazil was literally taken down by the ZIKA virus last year. The most important and basic thing is that we need to keep the mosquitoes out from the house by taking various methods. It is better to keep windows closed after evening and have the room air-conditioned. The virus keeps on mutating and gets adapted to the changes and this makes the condition even worse.

Friday, 12 May 2017

New Model Could Speed Up Colon Cancer Research

MIT

Colon cancer buster

Gene editing science has been an area of growth for genetic engineers and researchers across the globe. With progressing research studies, newer treatment options are being devised and successfully delivered. One such research conducted by MIT researchers have used new gene-editing systems to generate colon tumors, resembling human tumors. A new approach to a pre-existing method in genetic sciences. This paves the path for further investigation into knowledge about disease progression.

Metastases and detection:

The highest cause of death due to colon cancer is metastases, which is difficult to detect. The disease progression is so high, that fatality is hard to control even after various treatment procedures. A recent study by the director of Koch Institute, Tyler Jacks, uses similar CRISPR- based technology to build mouse models of the disease, revolutionizing research in the field of oncology.

Various approaches have been used for modeling cancer, one of them being the usage of cancer cell lines in lab dishes. This poses a lot of limitations. Another method used is mutations, which is then genetically engineered in the mice.

Recent studies involving CRISPR, which consists of DNA- cutting enzyme Cas9 and short RNA guide strands, which specialize in targeting specific genome sequences. Using the same method scientists can make targeted mutations, by either removing or adding genes. The genes for Cas9 are packaged into lentiviruses, which are then injected into target organs of the mice, transferred by colonoscopy.

What follows?

Gene editing makes this procedure possible. By virtue of which, after establishment of the tumor, mutations can be added or deleted, making the study process more complicated and informative. The information includes the aspects of metastases, initiation and progression of the tumor from liver to various parts of the body. This also helps in studying the pattern of metastases which again is peculiar in human colon.

The MIT team delivered organoids with a mutated form of the APC gene, which when established, were introduced in a mutated form of KRAS, commonly found in colon and many other cancers. These new approaches have cut short research time and has sped up the process of gene editing.

Implications:

Gene editing, this newest form of development in the field of oncology helps in drug testing, making it more successful. This ensures widening of treatment options. Factors such as age, metabolism, sex etc are also taken into consideration while conducting the study. This helps scientists choose best options for individual patients.

The mice are studied over a period of time to gain results, even though the study is supposed to be prolonged, various new discoveries and science have made it easier and faster. This helps in minimizing of side-effects post treatment and other health implications by three folds.

Genetic research shows a progressive growth over the years, showing immense scope and employment options. Diseases are getting detected sooner and treatment delivered on time. This in turn saves a lot of time, cost, manpower and patient care excels automatically.

Monday, 8 May 2017

Untreatable Superbug Infections on the Rise

Life-Taking Superbug is on the Go! 


With the increase in pollution, global warming, malnutrition, hybridization of vegetables and fruits the entire world is being engulfed by the vicious circle of health disorders. As per the data provided by NHS depicts, that there is a continuous increase in incurable superbug and this leads to the increase in number of sick people affected by CPE. The figures were where much less in 2002, where only 3 were heard to be affected by CPE per annum in 2002 and that has now increased to 2000 per annum. The data reveals that the life of almost every individual is at stake. The health syndromes are declining day by day with the rise in superbugs.

The Centers for Disease Control and Prevention based in US has suggested that 40 to 50 % of the patients inflicted by CPE infection in blood loses their life. The figures seem to increase day by day, as the 66 NHS Trusts in England, Public Health England said that since 2009, approximately 81 number of people succumbed to this deadly CPE disease and the numbers of death are increasing day by day heading up to 2000 every year.

The matter seems to get worst in coming days as Professor Nigel Brown, who is a member of the society for General Microbiology, says that the bacteria that carries CPE is almost everywhere. He also revealed an astonishing fact to the Sky News, saying that this bacterium is very much present in our guts and some of these CPE bacteria is strong enough to completely shatter the Carbapenem antibiotic by nullifying its capacity to fight these infectious superbugs.

These bacteria are so powerful that it gets transmitted into your blood from the gut and makes you sick enough to send you to the hospital and it is so infectious that it gets transmitted from one person to another by just a minor contact and once you are inflicted by these disease they spread rapidly and overpowers your entire body attacking your blood and then it finally becomes almost next to impossible to get immediate relief from its consequences. It breaks down your metabolism and curbs down the functioning of your entire system and the final destination is the hospitals bed and if the situation is not brought under control immediately then the patient can even die.

The death and survival rates are still not clear to depict that whether the survival rates have decreases or increased, as some health institutions have still not provided the accurate figures of death and survival rates so that a conclusion can be drawn to denote who is on the winning side the deadly superbug or the advanced medical treatments.

Emily Morris, who has survived in the case of superbug infection depending on antibiotics, shares her experience and she has acclaimed this sickness to be more powerful and hence it cannot be defeated so easily and in most cases death is inevitable. So, proper measures should be taken by the health experts to save the world from this life taking bug.

Friday, 5 May 2017

Artificial Womb That Can Keep the Premature Babies Alive





Artificial Womb
Test tube babies will become a thing of past with this innovation and breakthrough made by the scientists which might scare some people or make them happy altogether. Scientists had come up with an artificial womb which can keep pre term babies alive outside of the womb. The look and build of this device will remind the people of coming out right from any science fiction but it has been tested successfully on the baby lambs with impressive results. Very soon it will be made available for trails on the critically ill human babies coming from the age group of three to five years.

How does the artificial womb works?

The artificial womb is way ahead of the traditional incubators due to the use of the extra uterine support device which helps in closely replicating the conditions of the real womb. The next best thing introduced in this device is the presence of the external gas exchange machine which works just like the mother’s placenta and helps in keeping the blood circulation in the heart and body at optimum level. Scientists have ensured that there is no mechanical pump present in the device because studies have shown that even a gentle artificial pressure can turn fatal for the underdeveloped heart.

Scientists have made use of the synthetic amniotic which is filled with nutrients which essentially flows in as well as out of the temperature controlled of the bio bag kept in the near-sterile state. The aim of the scientists were to produce such an environment which can keep the premature babies safely outside the womb while their critical internal organs like lungs and heart develops to their best ability.

It is worth noting that babies born prematurely within 23 weeks posses a very weak chance of making through that alive. Thereby this system will certainly help in increasing the chances of the premature babies to develop healthily. This system is way superiors than the traditional technology and equipments available at the hospitals to take of the 23 week old baby.

Health industry experts are enthralled

One of the health industry experts has stated that there is certainly no technology which will eventually end up in replacing the mother’s womb right at the earliest stages of the fetal development. There are theories which are doing round in the past years wherein human can be reproduced artificially from the embryo completely. But such a thing is far from reality at the moment as human beings are way different from the lambs.

It is worth noting that lambs tend to grow faster taking just about five months to their full terms while it takes eight months for human. Secondly the lambs are way larger than the human baby at three times. One of the experts has also explained that this artificial womb is not designed to replace the womb required in the first half of the pregnancy rather it will help in specifically treating the extremely premature babies in a new ways.

Tuesday, 2 May 2017

Internet Crystal Ball Can Predict Risk of Heart Disease, Diabetes, Study Finds

Diabetes and cardiovascular disease predictions become easy with online crystal ball

Diabetes and heart disorders are now common problems to lots of people. And to cure these two diseases, many patients take medications almost regularly. Usually, we take steps, as soon as we determine any symptom of diabetes or heart-related diseases. However, now researchers have created a tool with the help of which you will be able to predict these diseases. They have introduced an online crystal ball that acts as metabolic calculator and has much power to know the possibilities of diabetes in a person. In fact, it works more precisely in compared to that of a conventional process.

Predict disease to stay safe-

The researchers of University of Florida and Virginia have invented this new system and they expect that it will allow many people to change their everyday lifestyle completely. Thus, lots of users may be able to keep away from the trouble and expenditures, which are associated with serious diseases.

In the past, cardiovascular problem, stroke and diabetes, were diagnosed, simply by having an observation at the blood pressure, cholesterol, HDL and obesity level of a person. Those, who have abnormalities, are found to have some metabolic disorder. They physicians inform them that they’ve quite higher risk of having health issues in future.

To explain something about the risk prediction, it is to be said that the physicians will be able to make out, if you may have cardiovascular issues in the coming years. Dr. Mark of UVA School has also informed that the doctors will be able to give much accurate data to the patients, who are vulnerable to the stated diseases. Thus, with more perception of the diseases, the patients also get motivation for making some adjustments.

How the calculator is different from traditional methods-

Traditional analysis is not effective to consider all the factors, like sex, race or background. It has been noted, Afro-American citizens do not show up metabolic issues in the diagnosis. However, still they have much possibility of cardiovascular syndrome and diabetes (Type 2).

But, the new crystal ball, invented recently, evaluates the usual risky issues and considers all the factors, like customs or gender. It is able to generate a comprehensible score that indicates metabolic seriousness. A research has detected that the predictions of web-based calculator are highly relevant with heart disease or diabetes issues. Another detailed study has involved thirteen thousand people for the experiment. The new tool has acted as a good predictor of diseases. The device includes scoring mechanism in order to work out the risk. All the information may be sent to doctors, who can take steps as preventive measures.

The calculator is accessible as free tool. More thorough study is needed to settle on accurate cut-off score for signifying the risk level. Though it is mainly healthcare experts, who have to use this, any person may utilize it to know about his health.

Thus, online crystal ball is a good innovation in the medical science to help many people, who have probability of experiencing diabetes and heart-oriented diseases.

Friday, 28 April 2017

High Quality Early Childhood Education has Significant Benefits

 Early Childhood
Modern daycare is characterized by process and quality orientation. In doing so, the contracts of education, education and care for each child must be guaranteed. Children's educational biographies are based on the findings of brain research in the first seven years of life. This is where the children's day-care centre comes to the fore as a preparation for school-based learning.

First, the present milieu deals with the conceptual explanation of relevant terms in the context of the elementary area. In the further course, the historical background of childcare will be discussed. The second part is devoted to the educational task of the kindergarten in the context of the latest findings of pedagogy and neurosciences. In the following, the question about the meaning and the effect of secure binding relationships for children with disabilities is presented and the findings of crib research are presented in relation to the theory of attachment. The postmodern perspective of seeing children as actively participating in their development becomes apparent in the context of the transition model. Research findings from the UK's Effective Provision of Pre-School Education (EPPE) study provide initial answers to the question of early childhood education, care and support.

The Elementary

According to Aden-Grossmann, the elementary area comprises all family-oriented pre-primary education, educational and care facilities, according to the kindergarten and comparable forms of child day care, from the age of three to the beginning of the school. It forms the lowest level of education and is characterized by an independent concept of education (elementary pedagogics). Thus, the various forms of child day care are recognized as educational institutions, but they are not fully integrated into the education system, but rather form a preliminary stage and remain associated with youth welfare.

Early childhood

The life cycle from birth to school is called early childhood. These are divided into the first six years of age (age 1), the infant (age 2 and 3) and the nursery or preschooler (age 4 to 6). Contrary to previous opinions, the knowledge that children from birth are independent subjects with specific competencies has become more and more popular today with the increasing cooperation between different disciplines (including neurobiology, pediatrics, child psychiatry and infant education). The paradigm shift in the everyday and scientific understanding is particularly noteworthy when, since the beginning of the 1990s, the concept of a "competent infant" has been developed, which is ready for learning and interacting immediately after birth. Thus neither passively nor alone to his instincts - a dominant view so far.

Until the beginning of the 21st century, further changes in the perspective of the early childhood complex have been made. In the field of early child hood education, the child has long been the focus of education and care. A trend is today's view that children in the first years of life are "people in a sensitive development phase” which is characterized by "extremely high learning ability". They need the protection of adults as well as adequate support, which encourages and accompanies them in their researcher urge. In this context, education is understood in a comprehensive sense, related to the emotional, cognitive and social development of the child.



Research Suggests Noninvasive Way to Suppress Epileptic Seizures

 Epileptic Seizures
Humans are mortal and so they are prone to diseases and disorders in the limited life span they have. However, some disorders become so critical that they are unable to get into order. Often we hear some deaths which are caused by the major diseases or the malfunctions in the body. This is something which should be prevented or taken care of in the earlier stage only. Epilepsy is one such disorder which can cause seizures in the brain.

THE SEIZURE

Well, the person after suffering from seizures will have the brain impacted. However, the main reason for the seizure is that the brain signals overshoot the normal limit. After that they create some sort of abnormal electrical activity which leads to the malfunction of the brain. They can create further twitches and convulsions.

THE CURE

Well, the science or the technology never fails to amuse us and so it has done in this time also undoubtedly. Thanks to the researchers or the scientists from the famous university of Carnegie and University of California, they have been able to come up with an exciting device which can help the multitude to mitigate the epileptic seizures with this non-invasive approach. The large number of neurons trigger the impulse in the brain and so the people suffer from the seizures. Their theory or the approach is based on a phenomenon commonly known as the Anderson localisation. The theory goes like this that how random disruptions of a medium can be the reasons for decreasing waves. The same concept was applied to curing of seizures.

THE STUDY

During the experiment done, the famous researchers have tried by simulating the activity of a tonic-clonic seizure known grand mal seizure. After that they changed the parameters which were responsible for triggering the neurons. It is always recommended to have the seizures cured in the early stages of life before something critical happens. This method is helpful as the seizure is experienced or during the onset of the triggering of neurons.

THE PROCESS

The patients are required to wear a device which would non-invasively suppress the seizures using a novel modality. It would launch a random pattern of the ultrasonic waves which would target the neurons. The doctors tried new paradigms which would interface the ones that are not prey to the conventional massive attacks. The researchers have brought together the very field of science, biology and maths to come up with this technique.

THE FUTURE

If the device is spread to the 50 million people who suffer from the epileptic seizures, it would be a great help. However, one should be guided in the most efficient manner to deal with this these epileptic seizures are mainly due to the collective pathological activity of the neuron. The researchers believe that the seizures can be cured in this fashion with the help of this device. But it has to be done during the onset of the seizures which would prevent people from further suffering.

Wednesday, 26 April 2017

An old drug with new potential: WWII chemical-weapon antidote shows early promise as treatment for spinal cord injuries

1

A New Medicine Built On Previous Grounds To Cure Spinal Cord Injuries.

A discovery in the field of medical science can never be forgotten, with new researches coming up in contemporary times; it may get old, but it will surely not lose its potential. Referring back to the old is a common phenomenon in every genre based on which new horizons can be explored.

Recent discovery has unveiled that a drug which was used during World War II to cure the pain and suffering that occurs due to severe injury taking place in your spinal cord. It works tremendously to retard neurotoxin that takes such a kind of injury to a different level of seriousness. This remarkable antidote is now leading to the evolution of a medicine that can cure several other injuries.

This drug is a potent suppresser of neurotoxin, also known as acrolein, that gets manufactured in our body when our nerve cells gets damaged and together with the formulation of neurotoxin if biochemical reactions also began to take place then your spinal cord’s injury will get worsen day by day. This is a very serious stage that can lead to paralysis if the seriousness of this injury is not brought under control. This can be life threatening as well.

The researchers have now discovered a new drug based on the same formula. Dimercapol is sure to keep in check all the toxins that builds up the chemical feature required for the formation of acrolein, instead transmits another toxin that will attack the toxins responsible for the formation of acrolein.

A professor of neuroscience and biomedical engineering in Purdue University, known as Riyi Shi; confirmed that Dimercapol is a very effective medicine that helps in eradicating acrolein and if fails to erase it completely then it helps in making the acrolein less toxic.

Shi has also confirmed that acrolein formation in the body has a severe drastic effect and leads to several other diseases to crop up. Pathologically it has a negative effect on your entire system and it also leads to health issues related to damaging of curtailing tissues, which in a way is responsible for the symptoms depicting serious illness. Sometimes the effects are such that it can lead to several other injuries in your body that has the capability to expand to the adjacent tissues.

Acrolein is responsible for disrupting a primary component known as lipids. The toxin is responsible for hampering lipids, which gets damaged because of the compounds, very commonly addressed as free radicals.

Free radicals are very dangerous for one’s health, as they are very reactive compounds to get generated after a trauma and leads to neurodegenerative diseases. Retarding of lipids is very close to several pathological problems occurring out of any severe trauma or diseases, the injuries and diseases includes spinal cord problems, traumatic injury of brain, several sclerosis and Alzheimer’s disease. The drugs that are responsible in performing the task of acrolein holders, is now considered as the most innovative strategy in keeping the concentration of neurotoxin under control.

Tuesday, 25 April 2017

Smart Tool Predicts Pregnancy Complications in Mothers

neonatal
Credit:Bridget Colla
Researchers at Queen Mary University of London had come together to develop which will help in saving both mother and babies lives. This tool effectively works by predicting whether the women in question are with early onset of the pre-eclampsia or are they fit to prolong their pregnancy. If you are wondering what eclampsia is then it is a condition which is known to affect as much as one per cent of the pregnant women and it is known to lead to extremely fata complication which might include the liver, kidney failure, lung problems, seizures and bleeding disorders.

How dangerous is pre-eclampsia?

Each year more than 1000 babies die due to complications rising from the pre-eclampsia. The PREP study conducted by team resulted in finding two highly successful method which helps in predicting the risk of the complications with an accuracy rate of the 84 percent among mothers. This research was funded by the National Institute for Health Research (NIHR) and it has already been published in the BMC medicine.

On the lead researcher associated with this study and development of the smart tool has stated that quite often babies are delivered prematurely which ultimately brings complications for the mother. Till today there is no robust test or guidelines to follow during the early birth scenario but the decision rest completely with the physician as well as mother in this regard.

It will be boon to the neonatal care

Currently the neonatal intensive care is in fragile state where one finds an acute shortage of the beds with higher hospital costs. Most of the hospital wards are concerned with the mother’s health and neonatal care takes a backseat. Secondly the cost of the facilities is so high that it becomes quite an expensive affair to check upon the pre-eclampsia tests.

Researchers had studied about 946 women who had shown the signs of early onset of the pre-eclampsia and they had been brought from 53 NHS trusts. Now the data was gathered for the participants through the team by carefully mentioning the age, gestation, blood pressure, liver & kidney function along with varied other parameters. The team of researchers were entrusted with the task of developing a mathematical model which will be able to predict the risk of complications in the participants who are the pregnant mothers.

How this smart tool works?

This tool has been named PREP model which will be helpful for the clinician in order to determine whether the mother is required to be transferred to the intensive maternal and neonatal care. The mother’s data and mathematical method will work together in analysing the mother’s health and it will help in figuring the high risk women from others.

Secondly the clinicians can make use of the PREP model in their regular practice through extremely well planned and robust clinical trials. This will help in understanding the subsequent rise of the pre-eclampsia among the pregnant women and it will also help in pre-emptive measure against it.

Wednesday, 12 April 2017

Researchers Develop New Solution for Independent Living: the ‘Empathetic Home’

Empathetic home to give more independence to the senior citizens

We know that with an increase of our age, we need special care to maintain our body. In some cases, the family members give an extra attention to their aged relatives. Sometimes, caregivers are also employed to look after the elderly people. However, now, it has become much easier for anyone to care for the aged persons.

TU/e is going to introduce a new way of living independently. The researchers of this university have suggested a special type of environment, which is called as empathetic home. This special setting is named so because it empathizes with elderly residents of a house. The technology, involved in it, works as a caregiver. According to the explanation, provided by the researchers, some sensors are to be installed on the floors and walls.

Best home for handicaps and aged persons-

The scientists have planned for this environment, considering the fact that lots of citizens in Netherlands are ageing. If we look back at the year, 2013, we may see that the age of more than 2 million people is over sixty five. It is assumed that by the year 2030, it will reach almost 4 million.

 That is why some guidelines are also given from government in order to allow the aged persons to survive independently. In case of handicaps also, the settings must enable them to spend time in a standard environment. But, the main problem is that there are not enough accommodation units, which are compatible to fulfill all the diverse needs of elderly citizens.

Empathetic home does all your jobs-

Masi Mohammadi, one of the members of TU/e, has said that a good home should offer not merely a roofing structure over our head. It’s really a good idea, if that house takes the responsibility of giving care to all the senior inhabitants. Masi also added that the empathetic design of home has the ability of recognizing the residents and giving them response to their requirements. It also helps people to do workouts and provides them with customized care to ensure healthy life.

The main target with empathetic home is to make the room automated. The technology, relevant to it, is referred to as smart. And it is to be integrated flawlessly to your house. It is also possible to regulate the requirements of all residents and to support them in their everyday activities.

Regions selected for testing the new home-

Masi Mohammadi has decided to express her own vision about the special home. That is why she wants to test out some concrete components, which are to be added to your home. However, there should be an exceptional association with 3 advanced centers, which are in three regions, Hertogenbosch, Roermond and Eindhoven zone. These are labs, where the output of this new innovation will be researched thoroughly.

The concept of edible wall is to be launched. It’s a wall with vertical garden that comprises herbs. Seniors do not need to give much effort for gardening. Besides, the smart flooring also allows prevents the possibilities of slip and fall accidents.

Monday, 10 April 2017

Modeling the Female Reproductive Tract

EVATAR
With the ever increasing and developing folds of science has suggested the fact that there is nothing in this world that can spare itself from the spell of scientific innovation. The scientific discoveries and researches are going to the extent of erasing the world of impossibilities. Soon there will be a time when there would not be any question whose answer will not be there with science. May that be any serious disease or any natural calamity everything can now be subjugated with the notches of scientific evolution surpassing all levels of revolution.

Menstruation is very common to every woman. It is a natural phenomenon that will take place in every woman’s life at the appointed time. There are only few who remain unattended by this natural occurrence. In Chicago one of the Northwestern medicine has revealed the fact that a female reproductive organ can be developed that is small enough to fit in the hands and has the capability to denote the future of research leading to curing of several diseases that occurs in a female reproductive organ. It is sure to make every impromptu situation change into an intended reality.

The scientists have named this scientific innovation EVATAR which based on technology and comprises of tissues of humans that will simultaneously lead to testing of the sustaining capacity of every new drug, to project how much reliable the medicine is to affect the reproductive system of a female.

EVATAR is also said to grasp the pulse of very disease that can occur in a female reproductory organ, measuring the intensity of diseases like endometriosis, fibroids (which is most commonly found in maximum women), cancer and even infertility.

The scientists have got the idea of this terrific revolution is by using the cells of an individual that will lead to the formation of an identical model similar to their reproductive system. EVATAR is said to comprise of ovaries of 3-D models, fallopian tubes, uterus, cervix, vagina and even liver that contains a unique kind of fluid that will pump blood from all the other parts mentioned so that the desired function can be performed. This EVATAR has a structure that of a cube which is not at all big.

The lead founder of this scientific innovation known as Teresa Woodruff, who is a named scientist of reproductive organs and also the director of the Women’s Health Research Institute; situated at Northwestern University Feinberg School of Medicine, suggests that this is no way a revolutionary innovation; rather she claims that this evolution is entirely based on the pre-existing theories of technology that sustains the whole idea of artificial formation of a naturally existing norms to deliver a natural result from all perspectives that will also cure several other diseases and problems that a woman has to go through just because of a natural formation that takes place in her body on which she does not have any control. She will have to accept what comes to her may that be good or bad, but due this innovation some problems can at least be dealt with if not all.

Wednesday, 5 April 2017

The Microbes in Your body That You Couldn’t Live Without

Microbial Life – Inside the Bowels

When Adam Rutherford took an uncomfortable test he discovered that for a healthy body full of good bacteria, one would need to do much more than consume probiotic yoghurt. It started off with what could be defined as an creative invention with a fold-out sheet having sticky tabs towards the front and back just like a flattened starfish. The tabs stick tend to stick to the seat of the loo and when it is in place, it is said to form a kind of hammock on which the specimen is offered, set for sampling.

He had slipped on the rubber gloves in preparation for the process. When he had left the deposit on the hammock a sample of the stuff with a small spoon attached to the inside of a blue lid of a test tube and wrapped in an icepack which was frozen earlier was dispatched - `Map My Gut which revealed what microbial life seemed to be inside the bowels.

Recently, numerous findings have indicated that the microbes in the digestive system seem to be more significant to our health and well-being than earlier presumed. On an average, we tend to have around one thousand different species of bacteria in our guts and in total though difficult to count could be around trillions. Most of it has been doing beneficial for us.

Microbes Help to Build Our Bodies

It is said that our genomes comprises of about 20,000 genes though our microbes tend to carry about 500 times more. This enables them to perform some tricks, they help to digest food, produce vitamins and minerals and even prevent us from suffering from some disorder by crowding and killing infectious bacteria. Moreover, they have also shaped who we are on the inside as well as the outside.

 Ed Yong, author of I Contain Multitude informs that our microbes help to build our bodies; they tend to sculpt and renew our organs as we tend to age. Besides, they may also influence our behaviour and the way we think. There have been several studies in animals portraying that microbes in the guts could influence their mood, personality and resilience to anxiety and stress.

But how much of these effects would carry in humans is still to be understood. However, we do tend to be aware that there is a much larger variation between people in our microbiome than there is in our genome.

Fermented Food – Healthy Microbiome

Makeup of our microbial is based on our medical history, our diet and our location. It is said to be a signature which could be very different to even our nearest relatives. Less than 100 species of bacteria tend to cause infectious disorder and the thousands of kinds of microbes located in our guts are according to author Douglas Adam, `mostly harmless’.

Top of the list of the most desirable are microbes such as Akkermansia and the Christensenellaceae which have been linked with protection against weight gain. Methanobrevibacter is said to be helpful in squeezing more calories from food which means that one could eat less while Oxalobacter tends to be helpful in the prevention of formation of kidney stones. For a healthy microbiome, fermented food is said to be especially good.

Monday, 3 April 2017

Scientists Identify Brain Circuit That Drives Pleasure-Inducing Behavior

Brain
Amygdala is that part of our brain which balances memory, emotional reactions and decision making processes and is responsible for making us stressed when we have that really important, or not so important, exam coming up. At least this is the train of thought scientists followed till the last 22nd March.

Graduate students Joshua Kim and Xiangyu Zhang authored a paper on an experiment supervised by Susumu Tonegawa, the Picower Professor of Biology and Neuroscience and a director at the RIKEN-MIT Center; which sheds new light on the activities of amygdala and show that they are hugely responsible to generate the happy feelings you get while biting on the piece of dark chocolate.

The experiment

The past body of research had been dedicated to unravel the circuitry of the brain from where negative behavior seemed to stem. Tonegawa and his team of neuroscientists from MIT conducted a groundbreaking research which has succeeded in confirming that amygdala consists of both reward and fear circuitry and is intricately involved in generating positive emotions.

Amygdala changed from the fear center of the brain to the reward generator in the experiment carried out by Tonegawa’s team on mice.Infact this research is a continuation of last year’s work where neurons from Basolateral Amygdala were thought to relay positive and negative information to nucleus of central amygdala.

Initially the central amygdala neurons were mapped into seven groups depending on the kind of genetic expression they point to. Then the mapped regions were exposed to optogenetics which basically uses light to control neural activity. What emerged from the experiment was five regions out of seven imitate reward related behavior which drove the mice to expose themselves more to light source. One region was found to be associated with fear related behavior.

Though about 90% of discovered amygdala tissue has been found to contribute to positive behavior, about 10% is still undiscovered and unmapped and according to Tonegawa the neural circuitry in the uncharted regions may be responsible to trigger negative emotions.

Generally, an amygdala can be said to exhibit appetitive behavior catering to satisfy the specific drive at an instant.

Aftermath of the experiment

The basolateral amygdala is being studied for the role it plays in fear extinction, which basically is a process used to overwrite the existing sets of fearful memories and replace it with positive ones and is used to treat cases of depression, post-traumatic stress disorder etc. Since the misconceptions about central amygdala acting as seat of negative stimuli has been invalidated, a new region called periaqueductal gray has emerged as research favorite to locate the pain and fear related stimuli.

The success of the experiment lies in firmly establishing the amygdala as a seat of positive stimuli and refuting its image as the fear center.Scientific community is elated at the new unexpected set of discovery. Scientists not officially related to the experiment have been quoted to find the new information to herald exciting times for brain research.